Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C

M Matthew L. Condakes Z Zhuo Zhang (College of Chemistry) D Derek B. Danahy R Richard R. Moore S Sirish Kaushik Lakkaraju X Xiaoliang Zhuo Y Yuka Amako (Discovery & Development Sciences) R Robert M. Borzilleri S Srividya B. Balachander L Lisa Chourb R Rita L. Civiello A Ashok R. Dongre D Daniel P. Downes D Dieter M. Drexler B Brianne M. Dudiak L Liudmila Dzhekieva M Miriam El-Samin B Brian E. Fink K Kosea Frederick C Cherrie Huang J Javed Khan E Emma Lees C Christopher G. Levins C Courtney McCarthy G Gabriel A. Mintier K Katherine Mosure M Michael F. Parker R Ryan Powles J Jie Qi M Max Ruzanov S Sanya Sharma S Steven Sheriff A Ashish K. Singh (Conway Institute, University College Dublin) J Justin Stedman N Nicolas Szapiel R Rebecca L. Thompson W Wayne Vaccaro T Tai Wang (New Cornerstone Science Laboratory, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871,) T Tianfu Yang D Dan You M Matthew J. Meyer J Joanne J. Bronson M Michelle L. Stewart