Coupled Hydrogen-Bond–Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics

X Xubo Tong (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) J Jiaqi Li Y Yingjia Tan (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) J Jie Mao (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) P Peiren Chen (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) Z Ziqi Yin (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) M Mengqian Wang (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) C Changwu Li (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) G Guihua Liu (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) Y Yongyi Yao (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) R Ruihan Gao (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering) Y Yingying Li S Siwei Guo (Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs) Y Yang Deng (Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs) W Wing-Leung Wong (Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China) P Pan Mao (Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs) X Xin Li J Junfeng Song (Lab of Advanced Materials, College of Smart Materials and Future Energy, Department of Chemistry) X Xinxin Feng (Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering)

Article Details

Volume / Issue Vol. 148, Issue 13
Published April 08, 2026
Pages 14662-14679
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (19)

X

Xubo Tong

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

J

Jiaqi Li

Y

Yingjia Tan

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

J

Jie Mao

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

P

Peiren Chen

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

Z

Ziqi Yin

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

M

Mengqian Wang

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

C

Changwu Li

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

G

Guihua Liu

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

Y

Yongyi Yao

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

R

Ruihan Gao

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering

Y

Yingying Li

S

Siwei Guo

Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs

Y

Yang Deng

Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs

W

Wing-Leung Wong

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China

P

Pan Mao

Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs

X

Xin Li

J

Junfeng Song

Lab of Advanced Materials, College of Smart Materials and Future Energy, Department of Chemistry

X

Xinxin Feng

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and College of Chemistry and Chemical Engineering