Corvis ST parameters in primary open angle and angle closure glaucoma after propensity score matching

Abstract

Abstract This retrospective study evaluated differences in Corvis ST tonometry (CST) parameters between eyes with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) using propensity score matching. We analyzed 48 eyes with POAG and 48 eyes with PACG. Twelve CST parameters were compared using linear mixed-effects models, with group as a fixed effect and subject ID as a random intercept to account for inter-eye correlation, adjusting for age, sex, axial length, intraocular pressure, and central corneal thickness. Multiple comparisons were controlled using the Benjamini–Hochberg procedure. Compared with POAG eyes, PACG eyes showed longer A2 time, greater A2 deformation amplitude, and greater whole-eye movement; however, these differences were no longer statistically significant after correction for multiple testing. After adjustment for relevant covariates and correction for multiple comparisons, this study did not demonstrate statistically significant differences in CST parameters between POAG and PACG eyes. The uncorrected trends toward greater indentation-related responses in PACG eyes should be regarded as exploratory.