Conversion of a Heme-Dependent Dehydratase to a Piperazate Synthase Reveals the Role of the Heme Propionate Group in N–N Bond-Formation

M Melanie A. Higgins N Nana Mirotadze (Department of Chemistry) X Xinjie Shi (Department of Microbiology) E Elesha R. Hoffarth (Department of Chemistry) Y Yi-Ling Du (The Fourth Affiliated Hospital and Institute of Pharmaceutical Biotechnology) K Katherine S. Ryan

Article Details

Volume / Issue Vol. 147, Issue 43
Published October 29, 2025
Pages 39160-39168
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (6)

M

Melanie A. Higgins

N

Nana Mirotadze

Department of Chemistry

X

Xinjie Shi

Department of Microbiology

E

Elesha R. Hoffarth

Department of Chemistry

Y

Yi-Ling Du

The Fourth Affiliated Hospital and Institute of Pharmaceutical Biotechnology

K

Katherine S. Ryan