Construction of Diverse Calcium‐Based Nanomaterials through a Microemulsion Method for Pyroptosis‐Initiated Antitumor Immunotherapy
Abstract
Abstract Calcium‐based nanomaterials have gained significant attention in biomedical fields due to their critical roles in biological processes and excellent biocompatibility. In this study, a universal and simple microemulsion approach is presented using calcium dodecylbenzenesulfonate as both surfactant and calcium source, enabling the synthesis of diverse calcium‐based nanomaterials (e.g., calcium succinate, calcium hypophosphite, calcium metatungstate, calcium gluconate, calcium formate, and calcium citrate). To address the challenges of inadequate immune response in tumor immunotherapy, calcium succinate nanoparticle (PCS NP) is investigated as an example. The PCS NP exhibit enhanced immunotherapeutic potential by activating the caspase‐1/GSDMD‐mediated pyroptosis pathway via calcium overload, which in turn enhanced the immune response. Additionally, the anionic succinate component upregulates major histocompatibility complex‐I (MHC‐I) expression, enhancing antigen presentation and alleviating the immunosuppressive tumor microenvironment (TME). This microemulsion strategy provides a novel platform for calcium nanomaterial fabrication, opening new avenues for TME‐regulated immunotherapy enhancement, demonstrating a broad application prospect.
Article Details
Authors (11)
Jing Li
Binbin Ding
State Key Laboratory of Rare Earth Resource Utilization
Pan Zheng
Key Laboratory of Superlight Materials & Surface Technology of Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Qi Meng
Hao Chen
Jia Tan
Wenying Zhang
State Key Laboratory of Rare Earth Resource Utilization
Xinyu Ma
Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Suzhou Key Laboratory of Soft Material and New Energy, College of Chemistry, Chemical Engineering and Materials Science
Jiashi Zhang
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
Ping'an Ma
Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China
Jun Lin
School of Chemistry and Life Resources