Concise Total Synthesis of (+)-Shearilicine: A Machine Learning-Assisted Strategy for Ligand Optimization of an Enantioselective Palladium-Catalyzed α-Arylation

Fu-Qiang Ni

Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China

Zhihao Wang

Center for Low-Carbon Conversion Science and Engineering; State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, Shanghai Advanced Research Institute

Zhenxun Li

College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China

Bing-Feng Zhang

Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry and Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, China

Pengpeng Zhang

College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China

Hai-Hua Lu

Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry and Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, China