Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins

Yu Shang Low; Solace G. Roche; Nadezhda A. Aleksandrova; Gabriel Foley; Jason KK Low; Joseph K. Box; Tristan I. Croll; Irene R. Chassagnon; J. Shaun Lott; Evelyne Deplazes; Mikael Bodén; Mark RH Hurst; Sarah J. Piper; Michael J. Landsberg

doi:10.1038/s41467-025-66050-x

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins

Y Yu Shang Low S Solace G. Roche N Nadezhda A. Aleksandrova G Gabriel Foley J Jason KK Low J Joseph K. Box T Tristan I. Croll I Irene R. Chassagnon J J. Shaun Lott E Evelyne Deplazes M Mikael Bodén M Mark RH Hurst S Sarah J. Piper (Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University) M Michael J. Landsberg (School of Chemistry and Molecular Biosciences, University of Queensland)

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published December 15, 2025

DOI 10.1038/s41467-025-66050-x

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (14)

Y

Yu Shang Low

S

Solace G. Roche

N

Nadezhda A. Aleksandrova

G

Gabriel Foley

J

Jason KK Low

J

Joseph K. Box

T

Tristan I. Croll

I

Irene R. Chassagnon

J

J. Shaun Lott

E

Evelyne Deplazes

M

Mikael Bodén

M

Mark RH Hurst

S

Sarah J. Piper

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University

M

Michael J. Landsberg

School of Chemistry and Molecular Biosciences, University of Queensland

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins

Article Details

Journal Info

Authors (14)

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