Comparison of mortality rates in the United States population suffering from Hodgkin's versus non-Hodgkin's lymphoma: A CDC Wonder database study from 1999-2020.

Abstract

e19068 Background: We conducted this study to compare the mortality rates among United States population suffering from Hodgkin’s and Non-Hodgkin’s lymphomas during a period of 1999 and 2020. Methods: CDC WONDER database was utilized to explore mortality rates standardized per 100,000 population in the United States. ICD-10 codes were used to identify multiple cause of death list on the death certificates. Patients were categorized as having Hodgkin’s lymphoma if cause of death listed is C-81 while non-Hodgkin’s lymphoma was included as C-82, C-83, C-84 and C-85. For age adjusted mortality rates (AAMR), US census standard population 2000 was used, and trends were represented as average annual percentage change (AAPC). Results: During the period of 1999 and 2020, a total of 561,521 patients died with non-Hodgkin’s lymphoma while 26,096 patients had Hodgkin’s lymphoma. The trends of mortality declined during the study period for both Hodgkin’s (from 0.51 to 0.25) and non-Hodgkin’s lymphoma (from 10.12 to 6.48). Males have slightly higher likelihood of mortality with Hodgkin’s lymphoma (57% vs 55%) as compared to females with non-Hodgkin’s lymphoma (45% vs 43%). Among racial differences, both Hispanics and White population reported higher mortality with Hodgkin’s lymphoma, however, White race is significantly affected with non-Hodgkin’s lymphoma and Asians are least affected by both Hodgkin’s and Non-Hodgkin’s lymphoma. Trends in mortality were higher in non-metropolitan areas and increasing in the recent years. In terms of Census Region, Midwest population had slightly higher proportional mortality with non-Hodgkin’s lymphoma while deaths with Hodgkin’s lymphoma have comparatively occurred more in West region. States in top 90 th percentile for mortality with Hodgkin’s lymphoma included Rhode Island, Vermont, Minnesota, Maine, and Wisconsin; while for non-Hodgkin’s lymphoma, the top states were Minnesota, Nebraska, Iowa, Ohio and Vermont. Conclusions: This retrospective study comparing mortality in Hodgkin’s and non-Hodgkin’s lymphoma over the past two decades demonstrates decreasing mortality trends for both diseases. Age adjusted mortality rates and trend comparison among Hodgkin's and Non-Hodgkin's Lymphoma. Variables Hodgkin Non-Hodgkin AAMR in 1999 AAMR in 2020 AAPC AAMR in 1999 AAMR in 2020 AAPC Total 0.51 0.25 -3.47* 10.12 6.48 -2.14* Male 0.89 0.51 -2.56* 12.95 8.68 -1.96* Female 0.54 0.30 -3.31* 8.07 4.82 -2.47* White 0.73 0.43 -2.88* 10.56 6.94 -2.02* Hispanic 0.77 0.40 -2.20* 7.55 5.60 -1.32* Black 0.61 0.39 -2.33* 7.64 4.74 -2.08* Asians 0.13 0.12 +1.28 6.12 4.35 -1.54* Metro 0.73 0.38 -3.00* 10.17 6.36 -2.25* Non-metro 0.64 0.46 -2.05* 9.90 7.26 -1.55* Northeast 0.76 0.42 -3.22* 10.39 6.46 -2.45* Midwest 0.77 0.40 -3.12* 10.91 7.24 -2.02* South 0.61 0.40 -2.18* 9.60 6.23 -2.01* West 0.74 0.40 -2.54* 9.85 6.34 -2.12* *indicates p<0.05.