Cold‐Induced Pyroelectric Stimulation Enhances Implant Osteointegration via TRPM8 Activation
Abstract
ABSTRACT Electrical signals serve as important modulators in bone regeneration, yet recreating this self‐sustaining bioelectrical microenvironment at the peri‐implant interface remains challenging. In this study, we engineered pyroelectric nanostructure coatings on titanium (Ti) implants to enhance implant osteointegration through temperature fluctuation‐driven electrical stimulation. The pyroelectric titanium (pyroTi) implants leverage the combined effects of the pyroelectric effect and cold stimulation to amplify calcium ion (Ca 2+ ) influx by activating cold‐sensitive transient receptor potential melastatin 8 (TRPM8) ion channel, therefore driving osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (BMSCs). As a demonstration, pyroTi used as a dental implant in the rabbit maxilla showed enhanced osteointegration under routine cold‐water intake. This study establishes a proof of concept for pyroelectric biomaterials that harness physiological temperature variations to potentiate bone‐implant integration.
Article Details
Authors (17)
Kai Li
Zishan Xu
Department of Biomaterials/Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases Jinan China
Xiaojia Liu
Key Laboratory of Sustainable Low-carbon Technologies for Textile Dyeing and Finishing, Ministry of Education, State Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering
Wenyan Xu
Department of Chemistry, University of California
Xueqing Wang
Jiajia Zhang
Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), School of Chemistry and Chemical Engineering
Yi Chen
Xiaoyi Liu
Department of Chemistry
Zhibang Li
Department of Biomaterials/Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases Jinan China
Danyang Wang
Lab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment, 266 Xinglong Section of Xifeng Road, Xi’an, Shaanxi 710126, P. R. China
Junkun Feng
Weiwei Zhao
Wenjun Wang
Junling Wu
Department of Biomaterials/Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases Jinan China
Shaohua Ge
Hong Liu
Jianhua Li