Co-occurrence of memory impairment and fatigue distinguishes post COVID from pandemic-related health effects in the 4-year CON-VINCE cohort study
Abstract
Abstract A major challenge in diagnosing post COVID lies in differentiating symptoms following a confirmed SARS-CoV-2 infection from those that may also occur in uninfected individuals (post COVID mimics) and be associated with a broader impact of the pandemic. The WHO post COVID definition was applied to the Luxembourgish longitudinal CON-VINCE cohort, where SARS-CoV-2 infection was confirmed via either a positive RT-qPCR or a serology test. Risk factor analysis was conducted on 1,865 individuals. Female gender, lower resilience, greater loneliness, and a higher number of comorbidities were associated with symptoms persistence. The symptomatology and comorbidity profiles of 559 participants (including 50 post COVID and 66 post COVID mimics) were investigated. Two distinct clusters of persistent symptoms were identified: (1) depression with anxiety, present in both infected and non-infected groups, and (2) memory impairment with fatigue, unique to the post COVID group. Therefore, presence of both memory impairment and fatigue may help differentiate post COVID patients from post COVID mimics. Yet, verification that memory impairment was newly developed was not possible, as this symptom was not recorded at baseline. Our findings suggest that future studies should consider factors affecting development of persistent post COVID-like symptoms observed in individuals that were never infected.
Article Details
Authors (182)
Patricia Martins Conde
Joëlle V. Fritz
Marc P. O’Sullivan
François Ancien
Venkata Satagopam
Jochen Klucken
Tamir Abdelrahman
Geeta Acharya
Gloria Aguayo
Pinar Alper
Wim Ammerlaan
François Anciens
Ariane Assele-Kama
Christelle Bahlawane
Katy Beaumont
Nadia Beaupain
Lucrèce Beckers
Camille Bellora
Fay Betsou
Luc Biver
Sandie Boly
Dirk Brenner
Henry-Michel Cauchie
Eleftheria Charalambous
Emilie Charpentier
Estelle Coibion
Sylvie Coito
Delphine Collart
Manuel Counson
Brian De Witt
Antonelle Di Pasquale
Olivia Domingues
Claire Dording
Jean-Luc Dourson
Bianca Dragomir
Tessy Fautsch
Jean-Yves Ferrand
Thibault Ferrandon
Ana Festas Lopes
Guillaume Fournier
Joëlle Véronique Fritz
Manon Gantenbein
Piotr Gawron
Laura Georges
Soumyabrata Ghosh
Stéphane Gidenne
Enrico Glaab
Clarissa Gomes
Borja Gomez Ramos
Vyron Gorgogietas
Jérôme Graas
Valentin Groues
Wei Gu
Gaël Hamot
Anne-Marie Hanff
Maxime Hansen
Linda Hansen
Lisa Hefele
Laurent Heirendt
Ahmed Hemedan
Estelle Henry
Margaux Henry
Eve Herkenne
Sascha Herzinger
Christiane Hilger
Laetitia Huiart
Alexander Hundt
Judith Hübschen
Gilles Iserentant
Philipp Jägi
Anne Kaysen
Piyapong Khurmin
Fédéric Klein
Tommy Klein
Stéphanie Kler
Alexey Kolodkin
Rejko Krüger
Pauline Lambert
Jacek Jaroslaw Lebioda
Sabine Lehmann
Marie Leick
Anja Leist
Morgane Lemaire
Andrew Lumley
Annika Lutz
João Manuel Loureiro
Monica Marchese
Tainà Marques
François Massart
Patrick May
Maura Minelli
Alessandra Mousel
Maeva Munsch
Sophie Mériaux
Friedrich Mühlschlegel
Mareike Neumann
Trang Nguyen
Beatrice Nicolai
Marc Paul O’Sullivan
Leslie Ogorzaly
Jochen Ohnmacht
Christiane Olesky
Markus Ollert
Claire Pauly
Laure Pauly
Lukas Pavelka
Christian Penny
Magali Perquin
Achilleas Pexaras
Palma di Pinto
Marie France Pirard
Jean-Marc Plesseria
Guilherme Ramos Meyers
Armin Rauschenberger
Lucie Remark
Antonio Rodriguez
Basile Rommes
Kirsten Rump
Estelle Sandt
Bruno Santos
Venkata P. Satagopam
Aurélie Sausy
Margaux Schmitt
Christiane Schmitt
Reinhard Schneider
Valerie Schröder
Serge Schumacher
Alexandra Schweicher
Sneeha Seal
Jean-Yves Servais
Florian Simon
Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Düsseldorf, University Hospital of Cologne, Cologne, Germany
Amna Skrozic
Chantal Snoeck
Kate Sokolowska
Lara Stute
Hermann Thien
Stéphane Toll
Noua Toukourou
Christophe Trefois
Johanna Trouet
Nguyen Trung
Jonathan Turner
Michel Vaillant
Daniela Valoura Esteves
Carlos Vega Moreno
Charlène Verschueren
Maharshi Vyas
Claus Vögele
Cécile Walczak
Xinhui Wang
Femke Wauters
Bernard Weber
Emilie Weibel
Tania Zamboni
Angelo Ferrari
Dmitry Bulaev
Maud Theresine
Robert Sega
Sabrina Saracino
Amy Parrish
Alexia Mendibide
Anna Schritz
Carlos Gamio
Carolina Coimbra
Clair Meek
Ekaterina Soboleva
François Neu
Gessica Contesotto
Guilherme Marques
Guillaume Nieser
Ilsé Richard
Mesele Valenti
Myriam Alexandre
Myriam Menster
Nassera Aouali
Olena Tsurkalenko
Olga Kofanova
Olivia Roland
Saïda Mtimet
Sonia Lamine
Valéry Bocquet
Victoria Lorentz