CLUES A Comprehensive Workflow for Integrating Geospatial Data in Biomedical Research
Abstract
Abstract Environmental exposures play a critical role in shaping physical and mental health, yet integrating such data into biomedical research remains technically complex and fragmented. The EnvironMENTAL Climate, Urbanicity, Environment and Society (CLUES) framework is an open-source, end-to-end workflow for generating individual-level environmental exposure data. CLUES automates the selection and download of open-access geospatial datasets, standardises spatial and temporal formats, and maps projections, and links resulting environmental variables to individual-level biomedical data, requiring no prior expertise in geospatial data. CLUES covers key environmental domains, including urban and natural space, climate and weather extremes, air pollution, and regional socioeconomic conditions. Designed for extensibility and cross-cohort applicability, it enables multidimensional exposure mapping across global settings and adheres to FAIR (Findability, Accessibility, Interoperability and Reusability) and privacy-compliant data protection principles. In this work, we present the CLUES framework and evaluate its scalability, computational performance, and reproducibility for large-scale biomedical research.
Article Details
Authors (85)
Marcel Jentsch
Elli Polemiti
Paul Renner
Sören Hese
Kerstin Schepanski
Roland Eils
Andre Marquand
Sven Twardziok
Gunter Schumann
Rieke Aden
Kofoworola Agunbiade
Ole A. Andreassen
Helga Ask
Anastasios-Polykarpos Athanasiadis
Tobias Banaschewski
Antoine Bernas
Sarah J. Böttger
Ragnhild Brandlistuen
Vince D. Calhoun
Xiao Chang
Beijing National Center for Condensed Matter Physics and Institute of Physics
Di Chen
Nina Christmann
Isabelle Claus
Nicholas Clinton
Yuxiang Dai
Department of Materials Physics and Chemistry, School of Materials Science and Engineering
Sylvane Desrivieres
Francisco José Eiroa-Orosa
Guillem Feixas
Sara Fernández-Cabello
Andreas J. Forstner
Jaime Gallego
Stefanie Heilmann-Heimbach
Andreas Heinz
Esther Hitchen
Per Hoffmann
Nathalie Holz
Reiya Itatani
Karina Janson
Tianye Jia
Viktor Jirsa
Hedi Kebir
Rikka Kjelkenes
Vanessa Köhler
Tristram A. Lett
Yuzhu Li
Carina M. Mathey
Andreas Meyer-Lindenberg
Abigail J. Miller
Frauke Nees
Maja Neidhart
Gaia Novarino
Markus M. Nöthen
George Ogoh
Myrto Patraskaki
Charlie Pearmund
Spase Petkoski
Markus Ralser
Michael A. Rapp
Jean-Charles Roy
Tamara Schikowski
Karen Schmitt
Ameli Schwalber
Emanuel Schwarz
Tatjana Schütz
Beke Seefried
Emin Serin
Mel Slater
Peter Sommer
Bernhard Spanlang
Bernd C. Stahl
Ulrike H. Taron
Paul Thompson
Heike Tost
Mira Tschorn
Nilakshi Vaidya
Dennis van der Meer
Henrik Walter
Lars T. Westlye
Department of Psychology, University of Oslo
Johannes H. Wilbertz
Yunman Xia
Allan H. Young
Xinyang Yu
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry
Jiacan Yuan
Yanqing Zhang
Zuo Zhang
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Key Laboratory of Polymer Chemistry & Physics, National Biomedical Imaging Center