Clinical outcomes for patients with hyperlipidemia and early-onset breast cancer: An analysis of the National Inpatient Sample.

Abstract

11184 Background: Despite recent global decreases in overall cancer incidence, the incidence of early-onset breast cancer (EOBC) is steadily increasing globally. Limited data is available on the comorbid correlations for this unfortunately expanding population. We sought to examine the national inpatient sample database to describe in-hospital outcomes among patients with EOBC and hyperlipidemia. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for 2019 and 2020. The NIS was searched for hospitalizations of adult patients with EOBC, defined as all-cause breast cancer in patients 50 years old or younger. We then examined the outcomes of patients who were noted to have hyperlipidemia. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality and secondary outcomes were annotated accordingly. SPSS software was used for statistical analysis, and all results were powered to p<0.001. Results: This study included 10,764 patients with EOBC, of which 1021 (9.49%) were found to have hyperlipidemia. Multivariate regression showed that patients with hyperlipidemia and EOBC had higher inpatient mortality (OR 1.052, CI 1.029-1.076, p<0.001). On secondary analysis, hyperlipidemia patients with EOBC were more likely to have anemia (OR 1.111, CI 1.099-1.123), thrombocytopenia (OR 1.095, CI 1.072-1.118), peripheral artery disease (OR 1.208, CI 1.074-1.359), hypertension (OR 1.433, CI 1.341-1.532), chronic kidney disease (OR 1.377, CI 1.280-1.481), acute renal failure (OR 1.159, CI 1.126-1.192), pancreatitis (OR 1.145, CI 1.048-1.251), pericarditis (OR 1.119, CI 1.069-1.172), intracranial hemorrhage (OR 1.148, CI 1.049-1.256), pulmonary hypertension (OR 1.213, CI 1.103-1.334), severe liver disease (OR 1.090, CI 1.076-1.104), leukemia (OR 1.188, CI 1.035-1.363), lymphoma (OR 1.138, CI 1.003-1.292), all-cause arrhythmias (OR 1.109, CI 1.068-1.152), all-cause shock (OR 1.065, CI 1.013-1.119), all-cause heart block (OR 1.257, CI 1.082-1.460), all-cause sepsis (OR 1.132, CI 1.113-1.152), all-cause coagulopathy (OR 1.118, CI 1.080-1.157), all-cause heart failure (OR 1.267, CI 1.202-1.336), all-cause stroke (OR 1.224, CI 1.159-1.292), and all-cause myocardial infarction (OR 1.413, CI 1.255-1.590). Conclusions: In this nationally representative, population‐based retrospective cohort study, hyperlipidemic patients with EOBC were associated with higher mortality and worse outcomes.