Circularly Polarized Luminescence with Large Dissymmetry Factor over 10 <sup>−1</sup> Based on Flexible Point‐Chirality via Programming at Molecular Level

S Shi‐Qiang Wei (Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China) Z Zi‐Hao Li (Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China) C Chun‐Lin Sun (State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China) Y Yae Li (State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China) X Xiao‐Yu Wang (Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China) D Ding Tong‐Mei (Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China) X Xuefeng Zhu Y Yong‐Qiang Tu (School of Pharmaceutical Sciences School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis Shanghai Jiao Tong University Shanghai China) S Shu‐Yu Zhang (School of Pharmaceutical Sciences School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis Shanghai Jiao Tong University Shanghai China)

Abstract

Abstract In this work, we report a series of small Spirocyclic Chiral Fluorophores (SCFs) with donor‐acceptor type small‐ π emitters. These SCFs induce mimic α ‐helix supramolecular packing modes via adjustments at the molecular level (e.g., hydrogen bonding sites, positions of fused rings). This approach not only enhances circularly polarized luminescence (CPL) with the luminescence dissymmetry factor ( g lum ) up to 0.18 in assembled materials but also enables inversion of the chiral signal. Moreover, unlike most CPL materials with a single point‐chiral center that are CPL‐silent at the molecular state, the spirocyclic configuration can enhance efficient point‐chirality transfer to the fluorophores owing to the self‐rigidified skeleton, consequently enable efficient CPL with the g l um in the order of 10 −3 even in the molecular solutions. The mechanistic insights are revealed by experimental investigation including the femtosecond transient absorption (fs‐TA) spectroscopy and single‐crystal analysis, as well as DFT calculation. This study opens new avenues for developing organic CPL materials with large g values based on low‐molecular‐weight flexible point‐chiral fluorophores, offering great potential for future applications in biotechnology and circularly polarized organic light‐emitting diodes (CP‐OLEDs).

Article Details

Volume / Issue Vol. 65, Issue 3
Published January 16, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (9)

S

Shi‐Qiang Wei

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China

Z

Zi‐Hao Li

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China

C

Chun‐Lin Sun

State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

Y

Yae Li

State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

X

Xiao‐Yu Wang

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China

D

Ding Tong‐Mei

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis &amp; School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China

X

Xuefeng Zhu

Y

Yong‐Qiang Tu

School of Pharmaceutical Sciences School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis Shanghai Jiao Tong University Shanghai China

S

Shu‐Yu Zhang

School of Pharmaceutical Sciences School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs State Key Laboratory of Synergistic Chem‐Bio Synthesis Shanghai Jiao Tong University Shanghai China