Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities

Abstract

Abstract Titanium dioxide nanoparticles (TiO2 NPs) are extensively incorporated in numerous industrial products. Adult male Albino rats received oral TiO2 NPs at a dose of 150 mg/kg body weight for 14 days exhibited both hepatic and renal toxicities manifested by disruption in serum hepatic and renal biomarkers, imbalance in oxidative-antioxidant system, up-regulation of mRNA expression of genes encode inflammation (IL-1β, TNF-α) and apoptosis (Caspase-3, BAX) with down-regulation of PCNA immune-staining density and histological modifications in hepatic and renal architecture. Carboxymethyl chitosan (5 mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO2 NPs – induced hepatic and renal dysfunction.