Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates

Mingjuan Du; Na Li; Tianqi Li; Zhuoqian Zhao; Huanzhen Liu; Xin Li; Nanxin Gong; Baoxin Duan; Wenli Wang; Yi Jian; Wenxuan Ma; Xiaoqi Zhang; Yi Wang; Zhaoyuan Zhang; Yiyang Bai; Xiaoqian Wang; Chunlei Wang; Jinming Liu; Xiangchen Guan; Feilong Zhou; Wei Wang; Lili Li; Xingping Zhu; Ying Lei; Yinkai Duan; Guoge Han; Pinghui Wei; Shan Gao; Sheng Wang; Ancheng Chen; Yi Huang; Haitao Yang; Xue Xue; Hongkai Zhang

doi:10.1038/s41467-025-67207-4

Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates

M Mingjuan Du N Na Li T Tianqi Li Z Zhuoqian Zhao H Huanzhen Liu X Xin Li N Nanxin Gong B Baoxin Duan W Wenli Wang Y Yi Jian W Wenxuan Ma X Xiaoqi Zhang Y Yi Wang Z Zhaoyuan Zhang Y Yiyang Bai X Xiaoqian Wang (School of Materials Science and Engineering) C Chunlei Wang (College of Sciences) J Jinming Liu (Department of Chemistry) X Xiangchen Guan F Feilong Zhou W Wei Wang L Lili Li X Xingping Zhu Y Ying Lei Y Yinkai Duan G Guoge Han P Pinghui Wei S Shan Gao S Sheng Wang A Ancheng Chen Y Yi Huang (Hubei Cancer Hospital Wuhan China) H Haitao Yang X Xue Xue (State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China) H Hongkai Zhang (Frontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and Academy for Advanced Interdisciplinary Studies)

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published December 10, 2025

DOI 10.1038/s41467-025-67207-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (34)

M

Mingjuan Du

N

Na Li

T

Tianqi Li

Z

Zhuoqian Zhao

H

Huanzhen Liu

X

Xin Li

N

Nanxin Gong

B

Baoxin Duan

W

Wenli Wang

Y

Yi Jian

W

Wenxuan Ma

X

Xiaoqi Zhang

Y

Yi Wang

Z

Zhaoyuan Zhang

Y

Yiyang Bai

X

Xiaoqian Wang

School of Materials Science and Engineering

C

Chunlei Wang

College of Sciences

J

Jinming Liu

Department of Chemistry

X

Xiangchen Guan

F

Feilong Zhou

W

Wei Wang

L

Lili Li

X

Xingping Zhu

Y

Ying Lei

Y

Yinkai Duan

G

Guoge Han

P

Pinghui Wei

S

Shan Gao

S

Sheng Wang

A

Ancheng Chen

Y

Yi Huang

Hubei Cancer Hospital Wuhan China

H

Haitao Yang

X

Xue Xue

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China

H

Hongkai Zhang

Frontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and Academy for Advanced Interdisciplinary Studies

Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates

Article Details

Journal Info

Authors (34)

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