Chessboard Microneedle Array for Inflammation Regulation via Spatiotemporally Controlled Drug Delivery
Abstract
ABSTRACT Excessive production of reactive oxygen species during photodynamic therapy (PDT) can exacerbate inflammation at the infection site and increase the risk of tumor metastasis, thereby posing significant challenges to treatment efficacy. In this study, a chessboard‐structured microneedle patch (HPC@PCN CMN) was designed using a micromolding technique. This design spatially separates and encapsulates photosensitizers and antioxidants within distinct fast‐ and sustained‐release microneedle systems, respectively, thereby achieving spatiotemporally ordered control of PDT and anti‐inflammatory treatment. Additionally, by adjusting the crosslinking degree of hyaluronic acid, the release rate of antioxidant drugs can be regulated, which facilitates a prolonged anti‐inflammatory effect. The results indicate that the anti‐inflammatory process of HPC@PCN CMN can alleviate inflammation by inhibiting the ATP‐P2RX4 pathway, demonstrating promising efficacy in the treatment of acne and melanoma. Overall, the developed chessboard microneedle platform is programmable, enabling not only the sequential regulation of oxidation‐antioxidation but also the potential for broader applications in drug‐delivery scenarios.
Article Details
Authors (12)
Yechun Jiang
School of Pharmacy Anhui Medical University Hefei Anhui P.R. China
Yongqi Gou
School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei Anhui P. R. China
Hui Shen
Yidie Wang
School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei Anhui P. R. China
Weinan Zhang
School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei Anhui P. R. China
Yayun Wu
Department of Critical Care Medicine The First Affiliated Hospital of Anhui Medical University Hefei Anhui P. R. China
Litao Liu
National Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University
Shu Fang
Department of Otolaryngology, University of Kentucky Medical Center
Ming Hu
Wanni Wang
School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei Anhui P. R. China
Lingling Xu
Jiangsu Provincial Key Laboratory of Green & Functional Materials and Environmental Chemistry, College of Chemistry and Materials
Haisheng Qian
School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei Anhui P. R. China