Chemoproteomics-Enabled <i>De Novo</i> Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer

B Brittney Racioppo (Department of Chemistry) D Dany Pechalrieu (Department of Chemistry) D Daniel Abegg B Brendan Dwyer (Skaggs Doctoral Program in the Chemical and Biological Sciences, Scripps Research, 10550 N Torrey Pines Road, La Jolla, California 92037, United States) N Neal Thomas Ramseier (Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States) Y Ying S. Hu (Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States) A Alexander Adibekian (Department of Chemistry)

Article Details

Volume / Issue Vol. 147, Issue 9
Published March 05, 2025
Pages 7817-7828
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

B

Brittney Racioppo

Department of Chemistry

D

Dany Pechalrieu

Department of Chemistry

D

Daniel Abegg

B

Brendan Dwyer

Skaggs Doctoral Program in the Chemical and Biological Sciences, Scripps Research, 10550 N Torrey Pines Road, La Jolla, California 92037, United States

N

Neal Thomas Ramseier

Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States

Y

Ying S. Hu

Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States

A

Alexander Adibekian

Department of Chemistry