Chemical‐Sensing Catheters for Long‐Term and Personalized Therapeutic Management
Abstract
ABSTRACT Long‐term intravenous catheterization is vital for delivering chemotherapy to cancer patients and parenteral nutrition to those with intestinal failure, but it inevitably leads to complications, including metabolic disorders, bloodstream infection, liver injury, and kidney injury. Clinical monitoring methods show notable delays, while real‐time blood monitoring devices fail to ensure long‐term stability in vivo. Here, we present a chemical‐sensing catheter that integrates multiple analyte sensors, including creatinine, taurocholic acid, bilirubin, and taurine, for real‐time monitoring of complications in patients receiving long‐term chemotherapy or parenteral nutrition in situ. The design of the metalgel preserves signal integrity through 1 million bending deformations, and a dual‐network molecularly imprinted polymer suppresses in vivo performance degradation, enabling stable long‐term operation of the chemical‐sensing catheter over a 3 month implantation period. In chemotherapy and parenteral nutrition applications, early monitoring of liver and kidney injury, combined with prognostic intervention, mitigates risks such as bile stasis, hepatitis, and hepatic steatosis. With the integration of machine learning analysis of multimodal sensor data, this technology provides early prediction of complications and establishes a new paradigm for personalized therapeutic management.
Article Details
Authors (25)
Yiran Li
Xinyin Cao
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Qianming Li
Xinyu Liu
Haifeng Sun
Yiding Jiao
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Guanheng Huang
Linfeng Han
School of Information and Communication Engineering University of Electronic Science and Technology of China Chengdu China
Jiang Lu
Kuangyi Zou
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Dan Li
Wenxuan Guo
Tingting Ye
Key Laboratory of Materials Physics
Jiacheng Wang
Zhejiang Key Laboratory for Island Green Energy and New Materials, Institute of Electrochemistry, School of Materials Science and Engineering
Er He
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Fangyan Li
Yuanzhen Wang
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Shuo Yang
Department of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, MOE Key Laboratory of High Performance Polymer Materials and Technology, School of Chemistry
Chenyu Bai
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Jie Song
Hangzhou Institute of Medicine
Xusong Li
National Laboratory of Solid‐State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing China
Hanting Zhang
Duke Univeristy, Durham, North Carolina, United States
Haidong Wang
Yuxia Zhang
Ye Zhang