Chemical Synthesis of Asymmetric Nucleosomes Reveals Intramolecular Activation of UHRF1 E3 Ligase by H3K9me3

Z Ziyu Xu (School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications) Z Zebin Tong (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) T Tianyi Zhang L Liying Zhang (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) Y Yun Liu J Jia-Bin Li H Huasong Ai (School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications)

Article Details

Volume / Issue Vol. 1, Issue 1
Published July 22, 2026
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

Z

Ziyu Xu

School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications

Z

Zebin Tong

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

T

Tianyi Zhang

L

Liying Zhang

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

Y

Yun Liu

J

Jia-Bin Li

H

Huasong Ai

School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications