ChatHTN: a consultation model for hypertension

D Dongmei Wang Z Zhongxu Yuan H Hua Deng (Fujian Key Laboratory of Atmospheric Ozone Pollution Prevention, Xiamen Key Laboratory of Indoor Air and Health, Institute of Urban Environment) Z Zhangjun Peng

Abstract

Abstract The rapid development of large language models (LLMs) has greatly advanced natural language processing (NLP). While these models perform remarkably well in tasks such as text generation and translation, they still face challenges in highly specialized domains such as hypertension, where domain expertise and personalization are crucial. To address these limitations, we introduce a generative framework for intelligent hypertension consultation that combines a domain-specific knowledge graph, a multi-task fine-tuning strategy, and a specialized dataset. The knowledge graph enhances the model’s medical knowledge, while the multi-task fine-tuning mechanism optimizes tasks like medical entity recognition and etiology classification to ensure consistency. To further strengthen reasoning ability, we construct HTN-5M, a large-scale Chinese dataset that embeds chain-of-thought (CoT) reasoning in a structured triplet format (input, output, CoT), supporting both question-answer generation and auxiliary learning. Experimental results demonstrate that our approach outperforms strong baselines, achieving a 16.25% improvement over DeepSeek-LLM-67B-base on the CMB benchmark and an approximate 10% gain over HuatuoGPT across three medical datasets.

Article Details

Volume / Issue Vol. 16, Issue 1
Published April 09, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (4)

D

Dongmei Wang

Z

Zhongxu Yuan

H

Hua Deng

Fujian Key Laboratory of Atmospheric Ozone Pollution Prevention, Xiamen Key Laboratory of Indoor Air and Health, Institute of Urban Environment

Z

Zhangjun Peng