Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation
Article Details
Journal Info
Journal of the American Chemical Society
American Chemical Society
Authors (14)
Mengyue Wu
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences
Ian Torrence
Department of Chemistry
Yuanning Liu
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences
Jingshuai Wu
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences
Rui Ge
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences
Ke Ma
Dong Liu
Hefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, National Synchrotron Radiation Laboratory
Jinwei Ren
State Key Laboratory of Microbial Diversity and Innovative Utilization
Shilong Fan
Ming Ma
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China
Justin B. Siegel
Department of Chemistry
Dean J. Tantillo
Department of Chemistry, University of California Davis, One Shields Ave. Davis, Sacramento, California 95616, United States
Wenhan Lin
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences
Aili Fan
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences