Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation

M Mengyue Wu (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) I Ian Torrence (Department of Chemistry) Y Yuanning Liu (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) J Jingshuai Wu (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) R Rui Ge (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) K Ke Ma D Dong Liu (Hefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, National Synchrotron Radiation Laboratory) J Jinwei Ren (State Key Laboratory of Microbial Diversity and Innovative Utilization) S Shilong Fan M Ming Ma (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China) J Justin B. Siegel (Department of Chemistry) D Dean J. Tantillo (Department of Chemistry, University of California Davis, One Shields Ave. Davis, Sacramento, California 95616, United States) W Wenhan Lin (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) A Aili Fan (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences)

Article Details

Volume / Issue Vol. 147, Issue 12
Published March 26, 2025
Pages 10413-10422
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

M

Mengyue Wu

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

I

Ian Torrence

Department of Chemistry

Y

Yuanning Liu

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

J

Jingshuai Wu

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

R

Rui Ge

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

K

Ke Ma

D

Dong Liu

Hefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, National Synchrotron Radiation Laboratory

J

Jinwei Ren

State Key Laboratory of Microbial Diversity and Innovative Utilization

S

Shilong Fan

M

Ming Ma

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China

J

Justin B. Siegel

Department of Chemistry

D

Dean J. Tantillo

Department of Chemistry, University of California Davis, One Shields Ave. Davis, Sacramento, California 95616, United States

W

Wenhan Lin

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

A

Aili Fan

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences