Ceramide disrupts TM9SF2-PGK1 axis to redirect PD-L1 trafficking and enhance antitumor immunity

Y Yi Zheng F Fan Yang M Mengmeng Wang (Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China) Z Zhiying Wang X Xindan Zhang (Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) C Chenxin Huo Y Yapeng Zhang A Aiqing Nie W Wenshuo Lyu A Anran Dong M Man Li Z Zhiyong Du S Shenghao Zhou L Luning Song W Wenpeng Jiang B Bowen Gu (Department of Stem Cell and Regenerative Biology, Harvard University) W Wei Zhao T Ting Dong (Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University)

Article Details

Volume / Issue Vol. 17, Issue 1
Published March 26, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (18)

Y

Yi Zheng

F

Fan Yang

M

Mengmeng Wang

Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China

Z

Zhiying Wang

X

Xindan Zhang

Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University

C

Chenxin Huo

Y

Yapeng Zhang

A

Aiqing Nie

W

Wenshuo Lyu

A

Anran Dong

M

Man Li

Z

Zhiyong Du

S

Shenghao Zhou

L

Luning Song

W

Wenpeng Jiang

B

Bowen Gu

Department of Stem Cell and Regenerative Biology, Harvard University

W

Wei Zhao

T

Ting Dong

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University