CDS-PD: a novel clinical decision support platform for Parkinson’s disease

D Deepak K. Gupta P Pedram Golnari K Katrina Prantzalos I Ian Zurlo V Vivikta Iyer B Brenna M. Lobb C Cole Zweber M Manu Bulusu D Dakota Clarke J James T. Boyd C Curtis Tatsuoka A Amie L. Hiller S Satya S. Sahoo

Abstract

Abstract The Movement Disorders Society clinical diagnostic criteria for Parkinson’s disease (MDS-PD) allow highly sensitive and specific diagnosis of Parkinson’s disease. However, their adoption has been limited due to lack of a clinical decision support (CDS) tool to support clinicians and researchers in systematically and accurately applying the MDS-PD criteria. We have developed and performed preliminary validation of a CDS platform for PD (CDS-PD) as a modular and extensible informatics platform with comprehensive functionalities for recording relevant patient information. We have performed real-time application of diagnostic algorithm of the MDS-PD criteria. The CDS-PD platform shows high concordance with application of the MDS-PD criteria by experienced movement disorders neurologists for established PD (disease duration ≥ 5 years). The CDS-PD platform is a step towards realizing the standardized electronic implementation of the MDS-PD criteria for PD patient care and clinical trials at point-of-care. The CDS-PD platform can be accessed after registration at weblink https://www.cdspd.org .

Article Details

Volume / Issue Vol. 16, Issue 1
Published January 28, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (13)

D

Deepak K. Gupta

P

Pedram Golnari

K

Katrina Prantzalos

I

Ian Zurlo

V

Vivikta Iyer

B

Brenna M. Lobb

C

Cole Zweber

M

Manu Bulusu

D

Dakota Clarke

J

James T. Boyd

C

Curtis Tatsuoka

A

Amie L. Hiller

S

Satya S. Sahoo