CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

Linjie Luo; Yan Wang; Tuyen Bui; Xiaoting Jiang; Mei-Kuang Chen; Xiayu Rao; Sepideh Mohammadhosseinpour; Mi Li; Serena Kim; Rachel Y. Kim; Saba Kamaliasl; Carmen W. Ulizio; Spyros Tsavachidis; Juliana Navarro-Yepes; Nicole M. Kettner; Hannah Wingate; Funda Meric-Bernstam; Kelly K. Hunt; Jing Wang; Kerrie Faia; Khandan Keyomarsi

doi:10.1038/s41467-025-67865-4

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

L Linjie Luo Y Yan Wang T Tuyen Bui X Xiaoting Jiang M Mei-Kuang Chen X Xiayu Rao S Sepideh Mohammadhosseinpour M Mi Li S Serena Kim R Rachel Y. Kim S Saba Kamaliasl C Carmen W. Ulizio S Spyros Tsavachidis J Juliana Navarro-Yepes N Nicole M. Kettner H Hannah Wingate F Funda Meric-Bernstam K Kelly K. Hunt J Jing Wang (Hunan Cancer Hospital Changsha China) K Kerrie Faia K Khandan Keyomarsi

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 22, 2026

DOI 10.1038/s41467-025-67865-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

L

Linjie Luo

Y

Yan Wang

T

Tuyen Bui

X

Xiaoting Jiang

M

Mei-Kuang Chen

X

Xiayu Rao

S

Sepideh Mohammadhosseinpour

M

Mi Li

S

Serena Kim

R

Rachel Y. Kim

S

Saba Kamaliasl

C

Carmen W. Ulizio

S

Spyros Tsavachidis

J

Juliana Navarro-Yepes

N

Nicole M. Kettner

H

Hannah Wingate

F

Funda Meric-Bernstam

K

Kelly K. Hunt

J

Jing Wang

Hunan Cancer Hospital Changsha China

K

Kerrie Faia

K

Khandan Keyomarsi

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

Article Details

Journal Info

Authors (21)

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