Catalytic Enantioselective Chlorofunctionalizations of <i>N</i>-Substituted Amides Using <i>In Situ</i> Generated HOCl as Hydrogen Bond Source

T Tengbo Ding (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy) L Liang Long (Science and Technology Innovation Center) M Mei-Jie Yuan (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy) W Wei Xu S Sze-Yung Wong (Department of Chemistry and State Key Laboratory of Synthetic Chemistry) H Hao Gao (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) Y Yong-Heng Wang (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) Y Ying-Yeung Yeung (Department of Chemistry and State Key Laboratory of Synthetic Chemistry) X Xiaojian Jiang (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy)

Article Details

Volume / Issue Vol. 147, Issue 19
Published May 14, 2025
Pages 16225-16236
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

T

Tengbo Ding

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy

L

Liang Long

Science and Technology Innovation Center

M

Mei-Jie Yuan

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy

W

Wei Xu

S

Sze-Yung Wong

Department of Chemistry and State Key Laboratory of Synthetic Chemistry

H

Hao Gao

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

Y

Yong-Heng Wang

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

Y

Ying-Yeung Yeung

Department of Chemistry and State Key Laboratory of Synthetic Chemistry

X

Xiaojian Jiang

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy