Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling

Shiju Ye; Yanbo Zhao; Hanxiao Tu; Xue Han; Tong Liu; Yingchao Gong; Jiangting Lu; Tingting Jin; Wu Luo; Xuefeng Qu; Dongwu Lai; Guosheng Fu; Guang Liang

doi:10.1038/s41467-026-70410-6

Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling

S Shiju Ye Y Yanbo Zhao (Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University) H Hanxiao Tu X Xue Han (State Key Laboratory of Advanced Chemical Power Sources, Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Academy for Advanced Interdisciplinary Studies, College of Chemistry) T Tong Liu Y Yingchao Gong J Jiangting Lu T Tingting Jin W Wu Luo X Xuefeng Qu D Dongwu Lai G Guosheng Fu G Guang Liang

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published March 24, 2026

DOI 10.1038/s41467-026-70410-6

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (13)

S

Shiju Ye

Y

Yanbo Zhao

Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University

H

Hanxiao Tu

X

Xue Han

State Key Laboratory of Advanced Chemical Power Sources, Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Academy for Advanced Interdisciplinary Studies, College of Chemistry

T

Tong Liu

Y

Yingchao Gong

J

Jiangting Lu

T

Tingting Jin

W

Wu Luo

X

Xuefeng Qu

D

Dongwu Lai

G

Guosheng Fu

G

Guang Liang

Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling

Article Details

Journal Info

Authors (13)

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