Carbene Insertion and Furyl Migration Cascade Toward Benzofurans
Abstract
Abstract Divergent access to complex molecular skeletons from the same set of readily available raw materials has been a primary goal of chemical synthesis, owing to their widespread application in drug research. In this study, a copper‐catalyzed insertion reaction of a disubstituted carbene into an unsaturated imine has been developed to form β,γ‐unsaturated carbonyl compounds with an α‐quaternary carbon center, which subsequently undergo an unprecedented forward 1,2‐/backward 1,4‐furyl migration cascade, ultimately affording a highly substituted benzofuran. A formal 1,3‐furan migration is involved in this multistep cascade sequence, broadening the substrate scope under mild reaction conditions.
Article Details
Authors (10)
Tu Zeng
School of Chemistry and Chemical Engineering Chongqing University 174 Shazheng Street Chongqing 400044 China
Shiqing Huang
Renmin University of China , , ,
Yingjian Gong
School of Chemistry and Chemical Engineering Chongqing University 174 Shazheng Street Chongqing 400044 China
Li Li
Keyi Guo
School of Chemistry and Chemical Engineering Chongqing University 174 Shazheng Street Chongqing 400044 China
Shitian Wu
School of Chemistry and Chemical Engineering Chongqing University 174 Shazheng Street Chongqing 400044 China
Huiyang Zhan
School of Chemistry and Chemical Engineering Chongqing University 174 Shazheng Street Chongqing 400044 China
Shiyu Xu
Xingcan Zhang
Sichuan Food Fermentation Industry Research & Design Institute Co., Ltd Chengdu Sichuan 610000 China
Baosheng Li
Chongqing University , , ,