Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer

Yu C. J. Chey; Bassam Kashgari; Louise McLeod; Georgette A. Radford; Linden J. Gearing; Ruby E. Dawson; Malvika Kharbanda; Joanne Lundy; Daniel Croagh; Charlotte Girard-Guyonvarc’h; Cem Gabay; Brooke A. Pereira; David Herrmann; Paul Timpson; John W. Finnie; Mohamed I. Saad; Dharmesh D. Bhuva; Bernardo S. Franklin; Florian I. Schmidt; Brendan J. Jenkins

doi:10.1038/s41467-026-69398-w

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer

Y Yu C. J. Chey B Bassam Kashgari L Louise McLeod G Georgette A. Radford L Linden J. Gearing R Ruby E. Dawson M Malvika Kharbanda J Joanne Lundy D Daniel Croagh C Charlotte Girard-Guyonvarc’h C Cem Gabay B Brooke A. Pereira D David Herrmann P Paul Timpson J John W. Finnie M Mohamed I. Saad D Dharmesh D. Bhuva B Bernardo S. Franklin F Florian I. Schmidt B Brendan J. Jenkins

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published February 07, 2026

DOI 10.1038/s41467-026-69398-w

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (20)

Y

Yu C. J. Chey

B

Bassam Kashgari

L

Louise McLeod

G

Georgette A. Radford

L

Linden J. Gearing

R

Ruby E. Dawson

M

Malvika Kharbanda

J

Joanne Lundy

D

Daniel Croagh

C

Charlotte Girard-Guyonvarc’h

C

Cem Gabay

B

Brooke A. Pereira

D

David Herrmann

P

Paul Timpson

J

John W. Finnie

M

Mohamed I. Saad

D

Dharmesh D. Bhuva

B

Bernardo S. Franklin

F

Florian I. Schmidt

B

Brendan J. Jenkins

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer

Article Details

Journal Info

Authors (20)

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