Broad spectrum structure discovery in large-scale higher-order networks

J John Hood C Caterina De Bacco A Aaron Schein

Abstract

Abstract Complex systems are often driven by higher-order interactions among multiple units, naturally represented as hypergraphs. Understanding dependency structures within these hypergraphs is crucial for understanding and predicting the behavior of complex systems but is made challenging by their combinatorial complexity and computational demands. In this paper, we introduce a class of probabilistic models that efficiently represents and discovers a broad spectrum of mesoscale structure in large-scale hypergraphs. The key insight enabling this approach is to treat classes of similar units as themselves nodes in a latent hypergraph. By modeling observed node interactions through latent interactions among classes using low-rank representations, our approach tractably captures rich structural patterns while ensuring model identifiability. This allows for direct interpretation of distinct node- and class-level structures. Empirically, our model improves link prediction over state-of-the-art methods and discovers interpretable structures in diverse real-world systems, including pharmacological and social networks, advancing our ability to incorporate large-scale higher-order data into the scientific process.

Article Details

Volume / Issue Vol. 17, Issue 1
Published April 27, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (3)

J

John Hood

C

Caterina De Bacco

A

Aaron Schein