Biosynthesis of Dothideomins Reveals a Fungal P450 That Constructs the Tricyclo[5.2.2.0.<sup>4,8</sup>]undecane-Imbedded Core Skeleton

F Falei Zhang (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) C Chuanteng Ma (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) M Meilin Zhu (School of Pharmacy) Y Yinghan Chen (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering) W Wenxue Wang (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) G Guojian Zhang (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) T Tianjiao Zhu (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) Q Qian Che (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China) D Dehai Li (School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China)

Article Details

Volume / Issue Vol. 147, Issue 8
Published February 26, 2025
Pages 7094-7102
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

F

Falei Zhang

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

C

Chuanteng Ma

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

M

Meilin Zhu

School of Pharmacy

Y

Yinghan Chen

State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering

W

Wenxue Wang

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

G

Guojian Zhang

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

T

Tianjiao Zhu

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

Q

Qian Che

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China

D

Dehai Li

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Sanya 266003, Qingdao 572025, P. R. China