Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications
Abstract
Abstract Since the discovery of 3D‐printing, it has revolutionized personalized drug delivery and implants by enabling intricate, customizable designs. However, key challenges remain, including complex design, host immune response, biofilm formation, and infection‐induced inflammation at the implant site. This work offers, first‐ever, unique ginger‐based 3D‐printable resins by chemically modifying Zingerol (Zing‐OH, a ginger‐based component) into photopolymerizable compositions that can print high‐resolution complex designs via DLP 3D‐printing. Briefly, the Zing‐OH is amended via different functional group backbones, resulting in Zing‐OH‐based resins (ether, ester, and urethane) and their respective prints. Moreover, the Zing‐OH prints’ thermal, mechanical, and biodegradation properties can be fine‐tuned by simply customizing the backbone. Furthermore, the shape memory efficacy and the human bone (nasal cartilage, vestibular, cortical, femur, etc.) mimicking mechanical properties (exhibiting 2–200 MPa compressive strength) makes them more enticing. In tandem, the prints are also hemocompatible as well as cyto‐friendly against human skin (HaCaT) and lung (BEAS‐2B) cells, and mouse fibroblast (NIH‐3T3) cells. Concurrently, an in vivo biocompatibility study in a rat model indicates that the printed materials are biocompatible, showing no signs of severe inflammatory response over a 28‐day period. More importantly, the outstanding anti‐biofilm and antioxidant efficacies of the Zing‐OH prints make them more appealing due to their potential to prevent implant rejection, thus making them promising tools for bone‐tissue engineering (BTE) applications.
Article Details
Authors (10)
Simran Jindal
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Majd Bisharat
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Bassma Khamaisi
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Krishanu Ghosal
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Eid Nassar‐Marjiya
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Qi Wu
Department of Pharmaceutical Sciences, University of Michigan
Shadi Daoud
Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences Galilee Medical Center Nahariya 2210001 Israel
Idan Redenski
Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences Galilee Medical Center Nahariya 2210001 Israel
Samer Srouji
Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences Galilee Medical Center Nahariya 2210001 Israel
Shady Farah
The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery Technologies, The Wolfson Faculty of Chemical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel