Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform

Y Yiwei Zhang (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) Y Yuqiu Lan (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) R Rufeng Fan (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) L Lei Feng G Guoliang Wang (School of Chinese Materia Medica) X Xinyuan Wu (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) L Lulu Wen (Tianjin University of Traditional Chinese Medicine) Z Zhiqiang Duan (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) Y Yueyue Xia (School of Chinese Materia Medica) X Xudong Wang L Lingrui Zhang (School of Chinese Materia Medica) L Lu Zhou (School of Pharmacy) M Minjia Tan (State Key Laboratory of Drug Research) C Cangsong Liao (State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica) X Xiaojie Lu (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica)

Article Details

Volume / Issue Vol. 147, Issue 48
Published December 03, 2025
Pages 44396-44405
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

Y

Yiwei Zhang

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

Y

Yuqiu Lan

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

R

Rufeng Fan

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

L

Lei Feng

G

Guoliang Wang

School of Chinese Materia Medica

X

Xinyuan Wu

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

L

Lulu Wen

Tianjin University of Traditional Chinese Medicine

Z

Zhiqiang Duan

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

Y

Yueyue Xia

School of Chinese Materia Medica

X

Xudong Wang

L

Lingrui Zhang

School of Chinese Materia Medica

L

Lu Zhou

School of Pharmacy

M

Minjia Tan

State Key Laboratory of Drug Research

C

Cangsong Liao

State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica

X

Xiaojie Lu

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica