Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease

Zachary Kostamo; Manuel A. Ortega; Chavonna Xu; Patricia R. Feliciano; Elizabeth Budak; Daisy Lam; Valerie Winton; Rebecca Jenkins; Archita Venugopal; Margaret Zhang; John Jamieson; Brent Coisman; Kennedy Goldsborough; Britney Hernandez; Celeste K. Kanne; Erica N. Evans; Jordan Zgodny; Yankai Zhang; Jawa Darazim; Ashwin Patel; Michael A. Pendergast; John Manis; Adam J. Hartigan; Giuseppe Ciaramella; Seung-Joo Lee; S. Haihua Chu; Vivien A. Sheehan

doi:10.1038/s41467-025-56578-3

Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease

Z Zachary Kostamo M Manuel A. Ortega C Chavonna Xu P Patricia R. Feliciano E Elizabeth Budak D Daisy Lam V Valerie Winton R Rebecca Jenkins A Archita Venugopal M Margaret Zhang J John Jamieson B Brent Coisman K Kennedy Goldsborough B Britney Hernandez C Celeste K. Kanne E Erica N. Evans J Jordan Zgodny Y Yankai Zhang (Department of Chemistry, Graduate School of Science, Kyoto University , Kyoto 606-8502,) J Jawa Darazim A Ashwin Patel M Michael A. Pendergast J John Manis A Adam J. Hartigan G Giuseppe Ciaramella S Seung-Joo Lee S S. Haihua Chu V Vivien A. Sheehan

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published February 07, 2025

DOI 10.1038/s41467-025-56578-3

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (27)

Z

Zachary Kostamo

M

Manuel A. Ortega

C

Chavonna Xu

P

Patricia R. Feliciano

E

Elizabeth Budak

D

Daisy Lam

V

Valerie Winton

R

Rebecca Jenkins

A

Archita Venugopal

M

Margaret Zhang

J

John Jamieson

B

Brent Coisman

K

Kennedy Goldsborough

B

Britney Hernandez

C

Celeste K. Kanne

E

Erica N. Evans

J

Jordan Zgodny

Y

Yankai Zhang

Department of Chemistry, Graduate School of Science, Kyoto University , Kyoto 606-8502,

J

Jawa Darazim

A

Ashwin Patel

M

Michael A. Pendergast

J

John Manis

A

Adam J. Hartigan

G

Giuseppe Ciaramella

S

Seung-Joo Lee

S

S. Haihua Chu

V

Vivien A. Sheehan

Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease

Article Details

Journal Info

Authors (27)

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