B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities

Jian Guan; Tiongsun Chia; Bin Li; Tianyu Zhu; Zhengguang Liao; Junjie Deng; Fenggen Fu; Weiwei Wu; Chengtao Liu; Ya Liu; Ninghuan Li; Lili Yue; Lei Cao; Jia Lu; Mengjia Zhu; Xiaomin Ling; Huilin Zheng; Shuming Lin; Li Li; Shuaixiang Zhou; Kaijie He

doi:10.1038/s41467-026-69703-7

B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities

J Jian Guan (Department of Environmental Science, Institute of Eco-Chongming, School of Ecological and Environmental Sciences) T Tiongsun Chia B Bin Li T Tianyu Zhu (Department of Chemistry) Z Zhengguang Liao J Junjie Deng (Joint Centre of Translational Medicine) F Fenggen Fu W Weiwei Wu C Chengtao Liu Y Ya Liu N Ninghuan Li L Lili Yue L Lei Cao J Jia Lu M Mengjia Zhu X Xiaomin Ling H Huilin Zheng S Shuming Lin L Li Li S Shuaixiang Zhou K Kaijie He

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published February 24, 2026

DOI 10.1038/s41467-026-69703-7

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

J

Jian Guan

Department of Environmental Science, Institute of Eco-Chongming, School of Ecological and Environmental Sciences

T

Tiongsun Chia

B

Bin Li

T

Tianyu Zhu

Department of Chemistry

Z

Zhengguang Liao

J

Junjie Deng

Joint Centre of Translational Medicine

F

Fenggen Fu

W

Weiwei Wu

C

Chengtao Liu

Y

Ya Liu

N

Ninghuan Li

L

Lili Yue

L

Lei Cao

J

Jia Lu

M

Mengjia Zhu

X

Xiaomin Ling

H

Huilin Zheng

S

Shuming Lin

L

Li Li

S

Shuaixiang Zhou

K

Kaijie He

B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities

Article Details

Journal Info

Authors (21)

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