Autonomous, Moisture‐Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing
Abstract
AbstractElectrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited in their clinical utility. This study introduces an autonomous, moisture‐driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist‐electric generator (MEG), an antibacterial hydrogel dressing, and concentric molybdenum (Mo) electrodes to provide a self‐sustaining electrical supply and potent antibacterial activity against Staphylococcus aureus and Escherichia coli. The MEG harnesses chemical energy from moisture to produce a stable direct current of 0.61 V without external input, delivering this therapeutic electrical stimulation to the wound site through the Mo electrodes. The AMFED facilitates macrophage polarization toward reparative M2 phenotype and regulates inflammatory cytokines. Moreover, in vivo studies suggest that the AMFED group significantly enhances chronic wound healing, with an approximate 41% acceleration compared to the control group. Using a diabetic mouse wound model, the AMFED demonstrates its effectiveness in promoting nerve regulation, epithelial migration, and vasculogenesis. These findings present a novel and efficient platform for accelerating chronic wound healing.
Article Details
Authors (10)
Ren Yan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases (R.Y.), The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xueliang Zhang
Hai Wang
Key Lab of Biomass Chemical Engineering of Ministry of Education and College of Chemical and Biological Engineering
Tikang Wang
Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 P. R. China
Guozhang Ren
Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 P. R. China
Qizeng Sun
Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 P. R. China
Fei Liang
State Key Laboratory of Crystal Materials and Institute of Crystal Materials
Yangzhi Zhu
Wei Huang
Hai‐Dong Yu
Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 P. R. China