Assessment of Gastroprotective Effects of Ethanolic Extract of Ipomoea pes-tigridis in Ethanol Induced Gastric Ulcer Model

Abstract

Common gastrointestinal disease peptic ulcer results from the misalignment between defensive functions of the gastric mucosa along with harmful elements which include high acid production with helicobacter pylori infection and oxidative stress. Proton pump inhibitors and antibiotics need replacement as treatments because they generate side effects and treatment resistence. This research investigates Ipomoea pes-tigridis potential for reducing gastric ulcers through experimental studies with Wistar albino rats exposed to ethanol. The extraction carried out using ethanol through Soxhlet apparatus, exhibited an extractive value of 28.64% w/w. The phytochemical screening revealed that the extract contains a wide range of phytoconstituents including alkaloids, carbohydrates, flavonoids, glycosides, proteins, saponins, tannins. The safety of the extract was evaluated through acute toxicity studies following OECD 423 guidelines. There are no signs of toxicity at the dose of 2000 mg/kg. The assessment of gastric parameters was carried out, it shows that the extract (IPM 400 mg/kg) having high gastrointestinal protection effect as like standard drug omeprazole. On gastric mucosa, the extract shows protective effect in dose dependent manner. On inflammatory markers, the extract helps to decrease the level of inflammatory markers like IL-6, TNF- α and IL-1β. The research validates ancient approaches using this plant for treating ulcers because it shows capacity for reducing ulcer index and acidic environment, cellular protective power, reduction in the level of inflammatory mediators. A well established study required to grow up the therapeutic value as well as feasibility of natural antiulcer treatment development.