Artificial Intelligence‐Assisted Workflow for Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling

M Marc Botifoll I Ivan Pinto‐Huguet (Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain) E Enzo Rotunno (CNR, Istituto Nanoscienze 2 , via G. Campi 213/a, 41125 Modena,) T Thomas Galvani (Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain) C Catalina Coll (Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain) P Payam Habibzadeh Kavkani (CNR Istituto Nanoscienze Via Campi 213/A 41125 Modena Italy) M Maria Chiara Spadaro (Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Catalonia Spain) Y Yann‐Michel Niquet (Univ. Grenoble Alpes CEA IRIG‐MEM‐L Sim Grenoble 38054 France) M Martin Børstad Eriksen (PIC, CIEMAT Campus UAB, Bellaterra Bellaterra 08193 Barcelona Catalonia Spain) S Sara Martí‐Sánchez (Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain) G Georgios Katsaros G Giordano Scappucci P Peter Krogstrup (NNF Quantum Computing Programme Niels Bohr Institute University of Copenhagen Copenhagen 1165 Denmark) G Giovanni Isella A Andreu Cabot (Catalonia Institute for Energy Research-IREC, Sant Adrià de Besòs, Barcelona 08930, Spain) G Gonzalo Merino P Pablo Ordejón (Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain) S Stephan Roche (Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST 1 , Campus UAB, Bellaterra, 08193 Barcelona,) V Vincenzo Grillo (CNR Istituto Nanoscienze Via Campi 213/A 41125 Modena Italy) J Jordi Arbiol (Catalan Institute of Nanoscience and Nanotechnology − ICN2 (CSIC and BIST), Campus UAB, Bellaterra, Barcelona, Catalonia 08193, Spain)

Abstract

Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of devices due to its time‐intensive nature. To address this, an analytical workflow is introduced for the holistic characterization, modelling, and simulation of device heterostructures. This workflow automates the experimental (S)TEM data analysis, providing an in‐depth characterization of crystallographic information, 3D orientation, elemental composition, and strain distribution. It reduces a process that typically takes days for a trained human into an automatic routine solved in minutes. Utilizing a physics‐guided artificial intelligence model, it generates representative descriptions of materials and samples. The workflow culminates in creating digital twins of systems limited with at least one axis of translational invariance –3D finite element and atomic models of millions of atoms–enabling simulations that provide crucial insights into device behavior in practical applications. Demonstrated with SiGe planar heterostructures for scalable spin qubits, the workflow links digital twins to theoretical properties, revealing how atomic structure impacts materials and functional properties such as spatially‐resolved phononic or electronic characteristics, or (inverse) spin orbit lengths. The versatility of the workflow is demonstrated through its application to a wide array of materials systems, device configurations, and sample morphologies.

Article Details

Volume / Issue Vol. 1, Issue 1
Published October 22, 2025
ISSN 0935-9648
Publisher Unknown Publisher

Journal Info

Advanced Materials

Unknown Publisher

ISSN: 0935-9648 Physical Sciences

Authors (20)

M

Marc Botifoll

I

Ivan Pinto‐Huguet

Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain

E

Enzo Rotunno

CNR, Istituto Nanoscienze 2 , via G. Campi 213/a, 41125 Modena,

T

Thomas Galvani

Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain

C

Catalina Coll

Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain

P

Payam Habibzadeh Kavkani

CNR Istituto Nanoscienze Via Campi 213/A 41125 Modena Italy

M

Maria Chiara Spadaro

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Catalonia Spain

Y

Yann‐Michel Niquet

Univ. Grenoble Alpes CEA IRIG‐MEM‐L Sim Grenoble 38054 France

M

Martin Børstad Eriksen

PIC, CIEMAT Campus UAB, Bellaterra Bellaterra 08193 Barcelona Catalonia Spain

S

Sara Martí‐Sánchez

Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain

G

Georgios Katsaros

G

Giordano Scappucci

P

Peter Krogstrup

NNF Quantum Computing Programme Niels Bohr Institute University of Copenhagen Copenhagen 1165 Denmark

G

Giovanni Isella

A

Andreu Cabot

Catalonia Institute for Energy Research-IREC, Sant Adrià de Besòs, Barcelona 08930, Spain

G

Gonzalo Merino

P

Pablo Ordejón

Catalan Institute of Nanoscience and Nanotechnology – ICN2 (CSIC and BIST) Campus UAB Bellaterra Barcelona 08193 Catalonia Spain

S

Stephan Roche

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST 1 , Campus UAB, Bellaterra, 08193 Barcelona,

V

Vincenzo Grillo

CNR Istituto Nanoscienze Via Campi 213/A 41125 Modena Italy

J

Jordi Arbiol

Catalan Institute of Nanoscience and Nanotechnology − ICN2 (CSIC and BIST), Campus UAB, Bellaterra, Barcelona, Catalonia 08193, Spain