Anti-fibrinolytic strategies improve liver regeneration in mice and reduce post-hepatectomy liver failure in patients
Abstract
Pharmacological plasminogen reduction enhanced liver regeneration experimentally and clinically. siRNA-induced plasminogen deficiency promoted hepatocyte proliferation after partial hepatectomy in mice, contrasting genetic deficiency models. In the HeLiX trial, tranexamic acid reduced post-hepatectomy liver failure odds, suggesting a novel therapeutic strategy.
Article Details
Authors (17)
Zhihao Li
Zimu Wei
Dafna J. Groeneveld
Michigan State University, East Lansing, Michigan, United States
Amy W Strilchuk
University of British Columbia, Vancouver, British Columbia, Canada
Matthew J. Flick
2Department of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Yawen Dong
Mayo Clinic, Rochester, Minnesota, United States
Vanja Podrascanin
Mayo Clinic, Rochester, Minnesota, United States
Mark Truty
Mayo Clinic
Michael L. Kendrick
Mayo Clinic, Rochester, Minnesota, United States
Sean P. Cleary
University Health Network, Toronto, Canada
Susanne G. Warner
Mayo Clinic, Rochester, Minnesota, United States
Rory L. Smoot
Mayo Clinic, Rochester, Minnesota, United States
Alice Assinger
Medical University of Vienna, Vienna, Austria
Christian J. Kastrup
Versiti Blood Research Institute, Milwaukee, Wisconsin, United States
Paul Karanicolas
Sunnybrook Health Science Centre, Toronto, Canada
James P. Luyendyk
Michigan State University, East Lansing, Michigan, United States
Patrick P. Starlinger
Mayo Clinic, Rochester, Minnesota, United States