Anisotropic Microcarriers: Fabrication Strategies and Biomedical Applications
Abstract
Abstract Anisotropic microcarriers (AMs) have attracted increasing attention. Although significant efforts have been made to explore AMs with various morphologies, their full potential is yet to be realized, as most studies have primarily focused on materials or fabrication methods. A thorough analysis of the interactional and interdependent relationships between these factors is required, along with proposed countermeasures tailored for researchers from various backgrounds. These countermeasures include specific fabrication strategies for various morphologies and guidelines for selecting the most suitable AM for certain biomedical applications. In this review, a comprehensive summary of AMs, ranging from their fabrication methods to biomedical applications, based on the past two decades of research, is provided. The fabrication of various morphologies is investigated using different strategies and their corresponding biomedical applications. By systematically examining these morphology‐dependent effects, a better utilization of AMs with diverse morphologies can be achieved and clear strategies for breakthroughs in the biomedical field are established. Additionally, certain challenges are identified, new frontiers are opened, and promising and exciting opportunities are provided for fabricating functional AMs with broad implications across various fields that must be addressed in biomaterials and biotechnology.
Article Details
Authors (15)
Yingying Hou
Leyan Xuan
Weihong Mo
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 P. R. China
Ting Xie
School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, U.K.
Juan Antonio Robledo Lara
Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA
Jialin Wu
Junjie Cai
Farzana Nazir
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 P. R. China
Long Chen
Department of Chemistry, Frontiers Science Center for New Organic Matter and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry
Xin Yi
Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture, Department of Pesticide Science, College of Plant Protection, South China Agricultural University
Sifan Bo
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 P. R. China
Huaibin Wang
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Yuanye Dang
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 P. R. China
Maobin Xie
Guosheng Tang