Analysis of computational tumor-infiltrating lymphocytes in breast cancer from the results of the TIGER challenge
Abstract
Abstract Tumor-infiltrating lymphocytes (TILs) is a recognized prognostic biomarker in breast cancer. However, poor interobserver agreement and limited reproducibility highlight the need for computational approaches. Despite advances, adoption of computational models has been hindered by lack of standardized methods and robust benchmarks. To address this, we launched TIGER, an international competition to build open-source computational TILs (cTILs) models. Here, we present a multi-centric analysis of cTILs methods on resections and biopsies from 3,708 human epidermal growth factor receptor 2-positive (HER2+) or triple-negative breast cancers (TNBC) from clinical practice and phase 3 trials. We report benchmarks on image analysis performance, show strong agreement of cTILs with pathologists, and demonstrate positive association of cTILs with neoadjuvant therapy response in HER2+, superior to visually scored TILs. We also show that cTILs add independent prognostic information to clinical variables in TNBC resections. Data, methods and benchmarks are publicly available: https://tiger.grand-challenge.org/ .
Article Details
Authors (76)
Witali Aswolinskiy
Leslie Tessier
Roberto Salgado
Francesco Ciompi
Mart van Rijthoven
Jeroen van der Laak
Maschenka Balkenhol
Joep M. A. Bogaerts
Damien Drubay
Laura Comerma Blesa
Dieter Peeters
Elisabeth Specht Stovgaard
Anne-Vibeke Lænkholm
Harry Haynes
Ligia Craciun
Denis Larsimont
Department of Pathology, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles
Mohamed T. Amgad
Lee AD Cooper
Cyril de Kock
Valerie Dechering
Johannes Lotz
Nick Weiss
Mieke van Bockstal
Christine Galant
Esther Lips
Hugo M. Horlings
Jelle Wesseling
Lennart Mulder
Sandra van den Belt
Karsten Weber
Paul Jank
Carsten Denkert
Institute of Pathology, Philipps University Marburg and University Hospital Marburg (UKGM), Marburg, Germany
Enrico Munari
Giuseppe Bogina
Chris Russ
Alex Lemm
Sherene Loi
Julia Dixon-Douglas
Stefan Michiels
Rogier Donders
Scott Maurits
Miriam Groeneveld
Anne Mickan
James Meakin
Bram van Ginneken
Heikki Joensuu
Ming Fan
Daehong Lee
Jaehyung Ye
Kangwon Byun
Jeongyeol Kim
Shuoyu Xu
Zheng Ji
Feng Xie
Jinbo Kuang
Xulin Chen
Liliang Chen
Arian Arab
Weijie Chen
Laboratory of Advanced Optoelectronic Materials, Suzhou Key Laboratory of Novel Semiconductor-optoelectronics Materials and Devices, State Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science
Victor Garcia
Nicholas Petrick
Brandon Gallas
Anna Maria Tsakiroglou
Richard Byers
Martin Fergie
Vishwesh Ramanathan
Anne L. Martel
Adam Shephard
Shan E. Ahmed Raza
Mostafa Jahanifar
Nasir M. Rajpoot
Sungduk Cho
Dong-Hee Kim
Hyungjoon Jang
Chanmin Park
Kyungdoc Kim