An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments

J Jingcheng Wang K Kaicheng Ma (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College) X Xiaomeng Cao H Huirui Wang (Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University) H Hao Shang (Shiyan Key Laboratory of Quantum Information and Precision Optics, Hubei Key Laboratory of Energy Storage and Power Battery, School of Optoelectronic Engineering and School of New Energy, Hubei University of Automotive Technology 1 , Shiyan 442002,) Y Yinghui Gao (Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University) M Mengmeng Wang (Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China) W Wenru Zhang K Kaige Lyu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College) Y Yue Dong G Guangkai Luo H Han Yu H Hui Li C Caixing An X Xindan Zhang (Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) Y Yingying Wu (Hefei National Research Center for Physical Sciences at the Microscale, CAS Center for Excellence in Quantum Information and Quantum Physics, and New Cornerstone Science Laboratory) J Jia Ren M Man Li T Ting Dong (Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University) P Peiyuan Zhang X Xiaohui Liu (Hydrogen Energy Industry Institute of Jilin Province)

Article Details

Volume / Issue Vol. 17, Issue 1
Published March 18, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

J

Jingcheng Wang

K

Kaicheng Ma

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

X

Xiaomeng Cao

H

Huirui Wang

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University

H

Hao Shang

Shiyan Key Laboratory of Quantum Information and Precision Optics, Hubei Key Laboratory of Energy Storage and Power Battery, School of Optoelectronic Engineering and School of New Energy, Hubei University of Automotive Technology 1 , Shiyan 442002,

Y

Yinghui Gao

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University

M

Mengmeng Wang

Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China

W

Wenru Zhang

K

Kaige Lyu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

Y

Yue Dong

G

Guangkai Luo

H

Han Yu

H

Hui Li

C

Caixing An

X

Xindan Zhang

Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University

Y

Yingying Wu

Hefei National Research Center for Physical Sciences at the Microscale, CAS Center for Excellence in Quantum Information and Quantum Physics, and New Cornerstone Science Laboratory

J

Jia Ren

M

Man Li

T

Ting Dong

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) and State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong University

P

Peiyuan Zhang

X

Xiaohui Liu

Hydrogen Energy Industry Institute of Jilin Province