An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

H Huiping Shuai J Jingxin Qiao C Chaemin Yoon G Guo Zhang Y Yuxin Hou (The State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Institute of Ecology, Peking University) X Xiaoyan Xia L Lei Wang X Xinyue Deng (Department of Chemistry, Institute of Molecular Aggregation Science, School of Science) Y Yifei Wang Q Qingquan Li L Lianzhao Du Y Yuanchen Liu M Minmin Zhou H Hoi Ting Wong J Jiaheng Hu H Huan Liu B Bingjie Hu (Laboratory of Mammalian Molecular Embryology, Department of Animal Science and Technology, College of Animal Sciences, Zhejiang University) D Dong Wang J Jingyi Su (School of Materials Science and Engineering) Y Yuying Pan Y Yongtao Ye Y Yan Chen Z Zhen Fang Z Ziyi Xia Y Yue Chai J Jialu Shi Y Yang Wang T Tianrenzheng Zhu H Honglei Zhang S Shuofeng Yuan J Jie Zhou J Jasper Fuk-Woo Chan (Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong) K Kwok-Yung Yuen (Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong) C Chunfu Xu (Institute for Protein Design and Department of Biochemistry) J Jian Lei (Department of Public Foundation) S Shengyong Yang H Hin Chu (Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong)