An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano‐Immunotherapy
Abstract
Abstract Spatiotemporal coordination of coherent steps in the cancer‐immunity cycle is desirable yet inherently challenging in nature, thereby impeding the effectiveness of immunotherapy in treating solid tumors. Here, this work designs an intelligent intracellular magnetic torque (IIMT) paradigm to spatiotemporally orchestrate tumor cells and antigen presenting cells (APCs) by integrating with rotating magnetic fields to drive immunotherapy. A rod‐shaped magnetic micromotor is engineered to manipulate tunable torques inside lysosomes and regulate selective biological functions in these cells. High‐intensity torques primarily cause tumor immunogenic cell death and antigen release, whereas, low intensity‐torques trigger antigen leakage from lysosomes for APC cross‐presentation and simultaneously activate NOD‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome. Importantly, sequential IIMT boosts antitumor immunity and synergistically enhances anti‐programmed cell death protein 1 antibody (anti‐PD‐1) therapeutic effect. In sum, this work develops a magnetic torque‐based strategy to drive the cancer‐immunity cycle for mechano‐immunotherapy, which opens an intriguing field to explore mechanobiology and immunity through intracellular mechanics.
Article Details
Authors (26)
Rui Gao
Chang Xu
Department of Chemistry, Anhui University, 111 Jiulong Road, Hefei 230601, P. R. China
Chen Liu
Zhenyan Zhu
State Key Laboratory of Autonomous Intelligent Unmanned Systems Frontiers Science Center for Intelligent Autonomous Systems Shanghai 201210 China
Min Wang
Xueyan Wei
Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University Shanghai 200434 China
Peng Ning
Wei Zhang
Yingze Li
Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University Shanghai 200434 China
Yajuan Zhang
Junwu Shen
Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University Shanghai 200434 China
Yifan Tong
Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.
Feng Tao
Xiaolei Chen
10Beijing Luhe Hospital, Capital Medical University, Beijing, China
Xiaoyi Jiang
School of Physics and Technology
Huan Ren
School of Engineering, Guangzhou College of Technology and Business , Foshan, Guangdong 528138,
Cheng Lv
Gustavo R. Plaza
Jason Miska
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
Haiming Fan
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials Science Northwest University Xi'an Shaanxi 710127 China
Xiaoqing Zhang
Yichao Tang
State Key Laboratory of Autonomous Intelligent Unmanned Systems Frontiers Science Center for Intelligent Autonomous Systems Shanghai 201210 China
Yalei Dai
Shanghai Key Lab of Tuberculosis Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China
Weiwei Yang
Bin He
Max Planck Institute for Chemical Physics of Solids
Yu Cheng
School of Chemistry and Chemical Engineering