Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity

F Fangfang Liu (Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology) G Guofang Zhang (Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology) X Xiaofeng Wang (Department of Medicinal Chemistry) D Dan Zhang (Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology) W Wuqiong Zhang (Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology) Q Qi Li C Cuiting Yang (Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology) M Muriel F. Gusta (Instiut Català de Nanociència I Nanotecnologia (ICN2)) N Neus G. Bastus (Instiut Català de Nanociència I Nanotecnologia (ICN2)) V Victor F. Puntes (Instiut Català de Nanociència I Nanotecnologia (ICN2)) Y Yang Li

Article Details

Volume / Issue Vol. 148, Issue 6
Published February 18, 2026
Pages 5881-5891
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (11)

F

Fangfang Liu

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology

G

Guofang Zhang

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology

X

Xiaofeng Wang

Department of Medicinal Chemistry

D

Dan Zhang

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology

W

Wuqiong Zhang

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology

Q

Qi Li

C

Cuiting Yang

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology

M

Muriel F. Gusta

Instiut Català de Nanociència I Nanotecnologia (ICN2)

N

Neus G. Bastus

Instiut Català de Nanociència I Nanotecnologia (ICN2)

V

Victor F. Puntes

Instiut Català de Nanociència I Nanotecnologia (ICN2)

Y

Yang Li