Ambient Light‐Activatable Luminescent Particle‐Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing
Abstract
ABSTRACT Biophotonic healthcare devices have been widely investigated for photochemical tissue bonding (PTB), photobiomodulation (PBM), photodynamic therapy (PDT), and photothermal therapy (PTT). However, their clinical applications remain limited due to the short light penetration depth and the incompliant light source, including externally powered light‐emitting diodes (LEDs). Here, we present a stretchable photonic patch embedded with biocompatible room light‐ and sunlight‐activatable luminescent particles (RSLPs) in an elastomeric matrix. This patch enables ambient light‐activatable phototherapy without an external light source by absorbing broadband ambient light and converting it into red luminescence. The emission promotes PTB, fibroblast proliferation, and M1/M2 macrophage polarization for tissue regeneration, activating photosensitizers to induce collagen crosslinking and wound sealing. The conformal patch maintains optical performance even under movement, enabling continuous phototherapy during daily life activity. Remarkably, after PTB‐driven sealing, wound healing is accelerated in both linear and circular wounds, mediated by PBM‐induced tissue regeneration. A further clinical study on normal human facial skins demonstrates that a single PBM treatment with the patch acutely improves viscoelastic recovery and attenuates superficial erythema. This ambient light‐activatable biophotonic patch platform would pave a big avenue toward PTB, PBM, and various biomedical applications.
Article Details
Authors (13)
Kyungjoo Jo
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Seong‐Jong Kim
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Seung Oh Jung
Department of Cosmetics Engineering Konkuk University Seoul Republic of Korea
Kyeongtaek Lee
Graduate Program of Medical Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Mungu Kim
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Kwanghyeon Park
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Yewon Seo
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Boram Park
Dongchul Jo
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Jongshin Kim
Graduate Program of Medical Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Jin Huh
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea
Hyemin Kim
Sei Kwang Hahn
Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea