ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

Isadora Lenoel; Matthieu Ribon; Félicie Lorenc; Aurélien Diebold; Clementine E. Philibert; David Robaldo; Manel Badsi; Julianne Perronnet; Julie Lameth; Felix Berriat; Hidemi Misawa; Marie Coutelier; Raphaelle Cassel; Nadège Sarrazin; Coline Jost-Mousseau; Delphine Bohl; Stéphanie Millecamps; Michel Mallat; David Brenner; Jochen H. Weishaupt; Séverine Boillée; Christian S. Lobsiger

doi:10.1038/s41467-025-63211-w

ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

I Isadora Lenoel M Matthieu Ribon F Félicie Lorenc A Aurélien Diebold C Clementine E. Philibert D David Robaldo M Manel Badsi J Julianne Perronnet J Julie Lameth F Felix Berriat H Hidemi Misawa M Marie Coutelier R Raphaelle Cassel N Nadège Sarrazin (Paris Brain Institute, CNRS, INSERM, Sorbonne Université) C Coline Jost-Mousseau D Delphine Bohl S Stéphanie Millecamps M Michel Mallat D David Brenner J Jochen H. Weishaupt S Séverine Boillée C Christian S. Lobsiger

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published August 26, 2025

DOI 10.1038/s41467-025-63211-w

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (22)

I

Isadora Lenoel

M

Matthieu Ribon

F

Félicie Lorenc

A

Aurélien Diebold

C

Clementine E. Philibert

D

David Robaldo

M

Manel Badsi

J

Julianne Perronnet

J

Julie Lameth

F

Felix Berriat

H

Hidemi Misawa

M

Marie Coutelier

R

Raphaelle Cassel

N

Nadège Sarrazin

Paris Brain Institute, CNRS, INSERM, Sorbonne Université

C

Coline Jost-Mousseau

D

Delphine Bohl

S

Stéphanie Millecamps

M

Michel Mallat

D

David Brenner

J

Jochen H. Weishaupt

S

Séverine Boillée

C

Christian S. Lobsiger

ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

Article Details

Journal Info

Authors (22)

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