AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape

Mohammad Sufyan Ansari; Varnit Chauhan; Aashi Singh; Areej Akhtar; Nisha Chaudhary; Reegina Tyagi; Divya; Kashif Husain; Sheetal Sharma; Ruquaiya Alam; Md Shakir; Mehak Pracha; Samreen Anjum; Mohd Nadeem; Prial Taneja; Md Imam Faizan; Iqbal Azmi; Aditya Ramdas Iyer; Pragya Gupta; Mehwish Nafiz; Shayan Ali; Insha Mohi Uddin; Momina Javid; Zahoor Ahmad Bhat; Hamenth Kumar Palani; Amit Kumar Srivastava; Ulaganathan Mabalirajan; Vikram Mathews; Mohammad Husain; Sivaprakash Ramalingam; Gaurav Kharya; Tanveer Ahmad

doi:10.1038/s41467-025-68272-5

AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape

M Mohammad Sufyan Ansari V Varnit Chauhan A Aashi Singh A Areej Akhtar N Nisha Chaudhary R Reegina Tyagi D Divya K Kashif Husain S Sheetal Sharma R Ruquaiya Alam M Md Shakir M Mehak Pracha S Samreen Anjum M Mohd Nadeem P Prial Taneja M Md Imam Faizan I Iqbal Azmi A Aditya Ramdas Iyer P Pragya Gupta M Mehwish Nafiz S Shayan Ali I Insha Mohi Uddin M Momina Javid Z Zahoor Ahmad Bhat H Hamenth Kumar Palani A Amit Kumar Srivastava U Ulaganathan Mabalirajan V Vikram Mathews M Mohammad Husain S Sivaprakash Ramalingam G Gaurav Kharya T Tanveer Ahmad

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 17, 2026

DOI 10.1038/s41467-025-68272-5

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (32)

M

Mohammad Sufyan Ansari

V

Varnit Chauhan

A

Aashi Singh

A

Areej Akhtar

N

Nisha Chaudhary

R

Reegina Tyagi

D

Divya

K

Kashif Husain

S

Sheetal Sharma

R

Ruquaiya Alam

M

Md Shakir

M

Mehak Pracha

S

Samreen Anjum

M

Mohd Nadeem

P

Prial Taneja

M

Md Imam Faizan

I

Iqbal Azmi

A

Aditya Ramdas Iyer

P

Pragya Gupta

M

Mehwish Nafiz

S

Shayan Ali

I

Insha Mohi Uddin

M

Momina Javid

Z

Zahoor Ahmad Bhat

H

Hamenth Kumar Palani

A

Amit Kumar Srivastava

U

Ulaganathan Mabalirajan

V

Vikram Mathews

M

Mohammad Husain

S

Sivaprakash Ramalingam

G

Gaurav Kharya

T

Tanveer Ahmad

AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape

Article Details

Journal Info

Authors (32)

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