Advanced heart disease classification based on multi-channel heart sound coupling features

Y Yu Fang D Dongbo Liu Z Zijian Guo (Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, School of Chemistry) H Hongxia Leng X Xing Liu X Xiaochen Wu

Abstract

Conventional heart sound classification methods often rely on single-channel, one-dimensional feature extraction, which inadequately captures pathological relationships across different auscultation zones, thereby limiting the accuracy of heart disease detection. To address this issue, a novel classification framework based on multi-channel heart sound coupling feature extraction is proposed to enhance heart disease identification. This approach begins with denoising preprocessing applied to four-channel heart sound signals and a single-channel electrocardiogram. These five-channel signals are systematically paired to extract five types of coupling features, resulting in 130 distinct features per multi-channel sample. The ReliefF algorithm is then used to evaluate feature importance, retaining the top 20% of features to construct a coupling feature set. A convolutional neural network is employed to classify normal and abnormal heart sounds. When applied to clinical congenital heart disease datasets, the proposed method achieved a classification accuracy of 95.6%, while on the PhysioNet heart sound challenge dataset, it reached an accuracy of 98.3%. Experimental results demonstrate that compared to single-channel, one-dimensional features, multi-channel coupling features more effectively capture pathological characteristics in heart sound signals, significantly improving the accuracy of heart disease classification and addressing challenges in the refined categorization of cardiac conditions.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 20, Issue 5
Published May 23, 2025
Pages e0321209
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (6)

Y

Yu Fang

D

Dongbo Liu

Z

Zijian Guo

Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, School of Chemistry

H

Hongxia Leng

X

Xing Liu

X

Xiaochen Wu