ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH

X Xiao Wen K Keyan Wu M Mengyao Wang (Key Laboratory of Applied Surface and Colloid Chemistry (MOE), School of Chemistry and Chemical Engineering) Z Zihan Ma T Tao Wang J Jing Zhang B Bei Wang (State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital) S Siyuan Chen J Jingyi Wang S Siyue Chen F Fan Yang C Chuwei Liu X Xianyang Chen L Lu Deng (Department of Animal Nutrition and Environmental Hygiene, College of Animal Science and Technology, Northwest A&F University) Y Yafan Cheng Q Qing Robert Miao B Baofa Sun X Xiongzhong Ruan K Kai Li Y Yajun Duan W Wenquan Hu