Access to <i>N</i> ‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives
Abstract
Abstract This work presents the first general synthetic access to N ‐CH₂F and N ‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N ‐CH 2 F and N ‐CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.
Article Details
Authors (4)
Filip G. Zivkovic
Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany
Fritz Bahns
Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany
Che‐Ming Hsu
Department of Chemistry National Sun Yat‐sen University Kaohsiung 80424 Taiwan ROC
Franziska Schoenebeck
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany